HIF-2α-IN-17

Overview

HIF-2α-IN-17 is a selective hypoxia-inducible factor 2α ( HIF2α ) inhibitor that binds to the PAS-B domain of HIF2α . HIF-2α-IN-17 disrupts the interaction between HIF2α and the molecular chaperone Hsp70 , leading to proteasomal degradation of HIF2α . HIF-2α-IN-17 exhibits antitumor activity and induces apoptosis in cancer cells. HIF-2α-IN-17 is applicable for research on cancers such as clear cell renal cell carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HIF/HIF Prolyl-Hydroxylase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > HSP | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-W470101
• CAS No.: 861212-49-9
• Molecular Formula: C17H14FN3O2
• Molecular Weight: 311.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source