4-Methylhistamine is a potent and selective agonist of histamine 4 receptor ( H4R ) with a K i of 50 nM. 4-Methylhistamine has a >100-fold selectivity for the hH4R over the other histamine receptor subtypes. 4-Methylhistamine can potently activate the hH4R ( pEC 50 = 7.4). 4-Methylhistamine can be used for the researches of cancer , inflammation and immunology, such as lung cancer and skin inflammation.
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