UNC-0638

Overview

UNC0638 is an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 treatment of a variety of cell lines resulted in lower global H3K9me2 levels, equivalent to levels observed for small hairpin RNA knockdown of G9a and GLP with the functional potency of UNC0638 being well separated from its toxicity. UNC0638 markedly reduced the clonogenicity of MCF7 cells, reduced the abundance of H3K9me2 marks at promoters of known G9a-regulated endogenous genes and disproportionately affected several genomic loci encoding microRNAs.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | HMTase

Product Information

• Catalog No.: B2693-456088
• CAS No.: 1255580-76-7
• Molecular Formula: C30H47N5O2
• Molecular Weight: 509.739
• Purity: 0.98
• Storage: Powder : -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
• Solubility: In Vitro : DMSO : ≥ 30 mg/mL (58.85 mM)

Source

Original product source