Benzo[a]pyrene diol epoxide

Overview

Benzo[a]pyrene diol epoxide is a carcinogen present in tobacco smoke as well as in environmental pollution. Benzo[a]pyrene diol epoxide is a metabolite of benzo[a]pyrene (BaP) , which is polycyclic aromatic hydrocarbon (PAH) . Benzo[a]pyrene diol epoxide induces esophageal carcinogenesis. Benzo[a]pyrene diol epoxide may act to induce activation of ERKs and p38 MAPK marked by an increased level of phosphorylation of both the ERKs and p38 MAPK which corresponds with the increased activation of both kinases as evidenced by increased phsosphorylation of their substrates Elk-1 and ATF-2, respectively.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Esophageal Cancer | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Others | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Environmental Pollutants

Product Information

• Catalog No.: HY-W585976
• CAS No.: 58917-67-2
• Molecular Formula: C20H14O3
• Molecular Weight: 302.32
• Purity: 99.98%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source