NSC 95397

Overview

NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor ( K i =32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC 50 =22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)). NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.

Application

Products | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Depression | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-108543
• CAS No.: 93718-83-3
• Molecular Formula: C14H14O4S2
• Molecular Weight: 310.39
• Purity: 99.0%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 10 mg/mL (32.22 mM); Clear solution
• Availability: In-stock

Source

Original product source