Chimmitecan

Overview

Chimmitecan is a potent topoisomerase I inhibitor. Chimmitecan is also an active metabolite of simmitecan. Chimmitecan displays outstanding activity in vitro and in vivo. The substitution at the 9-position benefits chimmitecan a salient anti-MDR activity, stability in human serum albumin, improved solubility, and oral availability, which might favorably promise its therapeutic potential in clinical settings. Source summary: Chimmitecan, a camptothecin derivative, acts as a topoisomerase I-inhibiting ADC payload for tumor-selective chemotherapy.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Topoisomerase

Product Information

• Catalog No.: B2693-462485
• CAS No.: 185425-25-6
• Molecular Formula: C23H20N2O5
• Molecular Weight: 404.42
• Purity: ≥95%
• Storage: Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
• Solubility: Soluble in DMSO, Water (Insoluble)

Source

Original product source