SC-60

Overview

SC-60 is a derivative of Sorafenib ( HY-10201 ). SC-60 exerts its anti-tumor effect by activating the phosphatase activity of SHP-1 , thereby inhibiting the STAT3 signaling pathway. SC-60 exhibits strong proliferation inhibitory activity in various hepatocellular carcinoma (HCC) cell lines. SC-60 downregulates the expression of downstream anti-apoptotic proteins (such as Bcl-2 , Cyclin D1 , Survivin ), ultimately inducing caspase -dependent apoptosis . SC-60 significantly inhibits tumor growth in xenograft tumor models. SC-60 can be used for the study of HCC.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Others | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Survivin | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > SHP1 | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-W717425
• CAS No.: 1421677-31-7
• Molecular Formula: C29H22N4O3
• Molecular Weight: 474.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source