GNE-781

Overview

GNE-781 is an orally active, highly potent and selective CBP inhibitor with an IC 50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC 50 s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model.

Application

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Product Information

• Catalog No.: HY-108696
• CAS No.: 1936422-33-1
• Molecular Formula: C27H33F2N7O2
• Molecular Weight: 525.59
• Purity: 98.51%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)
• Solubility: 2.5 mg/mL (4.76 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source