D-87503 is a potent inhibitor of PI3k/Akt/mTOR , with the IC 50 s of 62 nM and 0.76 μM, respectively for PI3k and Erk2 . D-87503 effectively suppressed the target downstream substrates Akt and Rsk1 kinase of the PI3k/Akt/mTOR signaling pathway.
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