TAK-448

Overview

TAK-448 is a KISS1R protein agonist as a oligopeptide analog of kisspeptin. In animal model, TAK-448 can stimulate LH/FSH release, whereas continuous sc exposure rapidly down-regulates the pituitary-gonadal axis, with rapid reduction of T levels in a dose-dependent manner. Phase II clinical trials for the treatment of Prostate cancer was discontinued. In Dec 2016, Takeda terminated a phase II trial in Hypogonadism (In adults, In the elderly) in USA because the study did not meet the primary endpoints. Sequence: Ac-Y-Hyp-NTFGLRW-NH2 Source summary: TAK-448 is a peptide compound involved in drug development targeting specific receptors in cancer research.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Kisspeptin Receptor

Product Information

• Catalog No.: B2693-475434
• CAS No.: 1234319-68-6
• Molecular Formula: C58H80N16O14
• Molecular Weight: 1225.36
• Purity: 98%
• Storage: Store at -20°C
• Solubility: Soluble in DMSO

Source

Original product source