Taminadenant

Overview

Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A 2A receptor (A 2A R) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with K B values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab ( HY-P9972 ). Taminadenant reactivate the antitumor immune response.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Signaling Pathways > Adenosine Receptor

Product Information

• Catalog No.: HY-109139
• CAS No.: 1337962-47-6
• Molecular Formula: C10H8BrN7
• Molecular Weight: 306.12
• Purity: 99.84%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (6.79 mM); Clear solution
• Availability: In-stock

Source

Original product source