XAV939

Overview

XAV 939 is a tankyrase (TNKS) inhibitor with IC50 values of 11 nM and 4 nM for tankyrase 1 and 2 respectively. XAV 939 antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It also suppresses proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Tankyrase-1

Product Information

• Catalog No.: B0084-212112
• CAS No.: 284028-89-3
• Molecular Formula: C14H11F3N2OS
• Molecular Weight: 312.31
• Purity: 0.98

Source

Original product source