BKM120

Overview

BKM120, also called as buparlisib or NVP-BKM120, activity in a range of preclinical cancer models, specifically inhibits class I PI3K isoforms, which blocks p110α (IC50 = 52 nM), p110β (IC50 = 166 nM), p110δ (IC50 = 116 nM) and p110γ (IC50 = 262 nM). BKM120 displays little sensitive to Class III and Class IV PI3K's or PI4K.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | PI3K

Product Information

• Catalog No.: B0084-438224
• CAS No.: 944396-07-0
• Molecular Formula: C18H21F3N6O2
• Molecular Weight: 410.39
• Storage: Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -42°C for long term (months to years).
• Solubility: Soluble to ≥80mg/mL in DMSO, to <1.2mg/mL in Water, to ≥22mg/mL in Ethanol

Source

Original product source