DAP-81

Overview

DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Polo-like Kinase (PLK)

Product Information

• Catalog No.: B0084-462333
• CAS No.: 794466-17-4
• Molecular Formula: C25H20N6O4
• Molecular Weight: 468.464
• Purity: 98%

Source

Original product source