venetoclax

Overview

Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, a protein commonly overexpressed in cancer cells, to induce programmed death of CLL cells. Venetoclax is used as a second-line treatment of chronic lymphocytic leukemia (CLL).

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Bcl-2 Family

Product Information

• Catalog No.: B0084-462638
• CAS No.: 1257044-40-8
• Molecular Formula: C45H50ClN7O7S
• Molecular Weight: 868.44
• Solubility: 10mM in DMSO

Source

Original product source