Lonafarnib

Overview

Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Farnesyl Transferase

Product Information

• Catalog No.: B2693-086642
• CAS No.: 193275-84-2
• Molecular Formula: C27H31Br2ClN4O2
• Molecular Weight: 638.829
• Purity: > 95%
• Solubility: ~3mg/ml

Source

Original product source