foretinib

Overview

Potent inhibitor of MET, VEGFR2, Ron and AXL (IC50 values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFRalpha and PDGFRbeta. Inhibits migration and invasion of B16F10 melanoma cells in vitro. Suppresses B16F10 tumor growth and metastasis in mice.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | c-Met/HGFR

Product Information

• Catalog No.: B2693-152657
• CAS No.: 849217-64-7
• Molecular Formula: C34H34F2N4O6
• Molecular Weight: 632.665

Source

Original product source