GW-405833

Overview

GW-405833 (L768242) is a potent, selective cannabinoid receptor 2 ( CB 2 ) agonist. GW405833 has EC 50 and K i values ​​of 0.65 nM and 3.92 nM for CB 2 , and EC 50 and K i values ​​of 16.1 μM and 4772 nM for CB 1 . GW-405833 also exhibits non-competitive CB 1 antagonist, exerting its analgesic and and anti-inflammatory effect through a CB 1 receptor (rather than CB 2 ) dependent mechanism. GW-405833 can significantly inhibit the production of cAMP stimulated by Forskolin ( HY-15371 ). GW405833 inhibits glycolysis by down-regulating HIF-1α , thereby alleviating acute liver failure (ALF).

Application

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Product Information

• Catalog No.: HY-110036
• CAS No.: 180002-83-9
• Molecular Formula: C23H24Cl2N2O3
• Molecular Weight: 447.35
• Purity: 98.91%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source