ZK-Thiazolidinone

Overview

ZK-Thiazolidinone is an ATP-competitive Polo-like kinase 1 ( Plk1 ) inhibitor with an IC 50 of 19 nM. ZK-Thiazolidinone inhibits tumor cell proliferation, induces cell cycle arrest and typical mitotic defects. ZK-Thiazolidinone impairs the recruitment of γ-tubulin and Aurora A kinase to centrosomes, resulting in failure of bipolar spindle maintenance and sister chromatid arm cohesion.\nZK-Thiazolidinone is applicable for cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Polo-like Kinase (PLK)

Product Information

• Catalog No.: HY-104023
• CAS No.: 891849-87-9
• Molecular Formula: C23H26F3N5O2S
• Molecular Weight: 493.55
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source