PF-562271 mesylate

Overview

PF-562271 mesylate (VS-6062 mesylate) is an orally active, ATP-competitive, reversible FAK / Pyk2 inhibitor, with an IC 50 of 1.5 nM for FAK and 13 nM for Pyk2 . PF-562271 mesylate induces tumor regression, and inhibits tumor growth, invasion and metastasis. PF-562271 mesylate exerts no effect on tumor necrosis, angiogenesis or apoptosis in an orthotopic mouse model of pancreatic ductal adenocarcinoma. When combined with Sunitinib ( HY-10255A ), PF-562271 mesylate reduces tumor vascularization, decreases serum alpha-fetoprotein levels and improves cachexia. PF-562271 mesylate can be used in research related to prostate cancer , breast cancer , pancreatic cancer , colon cancer , glioblastoma, lung cancer , pancreatic ductal adenocarcinoma and hepatocellular carcinoma.

Application

Products | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Glioma | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Pancreatic Ductal Adenocarcinoma | Products > Disease Areas > Glioblastoma | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Pancreatic Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > FAK | Products > Signaling Pathways > Pyk2

Product Information

• Catalog No.: HY-10459A
• CAS No.: 939791-39-6
• Molecular Formula: C22H24F3N7O6S2
• Molecular Weight: 603.59
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source