MRS2768

Overview

MRS2768 is a potent, selective, and metabolically stable P2Y 2 receptor agonist with an EC 50 of 1.89 μM for the human P2Y 2 receptor. MRS2768 activates Gq/PLC/PKC signaling, leading to downstream phosphorylation of Akt , eNOS , and ERK , with effects varying by cell type. MRS2768 inhibits ENaC via Gq/PKC/Src/Akt to promote natriuresis and lower blood pressure in the kidney. MRS2768 activates eNO S to increase NO secretion in endothelial cells. MRS2768 drives proliferation via PI3K/Akt in fibroblasts and cancer cells. MRS2768 exerts anti- apoptotic effects through PKC/Src/Akt in cardiomyocytes. MRS2768 can be applied to investigate P2Y 2 -dependent pathological processes, including acute kidney injury, chronic kidney disease and renal fibrosis, DOCA-salt induced hypertension, myocardial infarction, pulmonary arterial hypertension, pancreatic cancer , cardiac fibrosis, dry eye disease, as well as shear stress-mediated vascular remodeling and atherosclerosis.

Application

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Product Information

• Catalog No.: HY-108649
• CAS No.: 1047980-83-5
• Molecular Formula: C15H20N2O18P4
• Molecular Weight: 640.22
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source