SNX-7081

Overview

SNX-7081 is an Hsp90 inhibitor with K i and IC 50 values of 26 nM and 44 nM, respectively. SNX-7081 blocks the nuclear translocation of NF-κB , inhibits the production of pro-inflammatory cytokines, attenuates the ERK / JNK and PDGF signaling pathways, and suppresses LPS ( HY-D1056 )-induced nitric oxide production. SNX-7081 inhibits DNA repair, induces G 2 /M cell cycle arrest, and triggers apoptosis via downregulation of MYC /nucleolin and activation of Fas . SNX-7081 can be used in research related to rheumatoid arthritis and cancer .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Rheumatoid Arthritis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > ERK | Products > Signaling Pathways > JNK | Products > Signaling Pathways > PDGFR | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > HSP

Product Information

• Catalog No.: HY-111165
• CAS No.: 908111-22-8
• Molecular Formula: C24H31N3O3
• Molecular Weight: 409.53
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source