DC-34

Overview

DC-34 is a selective stabilizer of MYC G-quadruplexes ( G4s ), with measured K d values of 9.4 μM (FIA), 1.4 μM (SPR), and 16.5 μM (NMR) across different assays. DC-34 downregulates MYC levels in cancer cells in a G4-dependent manner, reduces cell viability, and induces G0-G1 cell cycle arrest and p16-marked senescence in MYC-driven multiple myeloma cells. DC-34 can serve as a probe for G4-dependent gene regulation studies and is applicable to research on multiple myeloma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > G-quadruplex | Products > Signaling Pathways > c-Myc

Product Information

• Catalog No.: HY-115569
• CAS No.: 1966107-70-9
• Molecular Formula: C24H25F3N2O3
• Molecular Weight: 446.47
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source