AS1604498

Overview

AS1604498 is a highly specific competitive inhibitor of human NAMPT , with an IC 50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis . AS1604498 is applicable to research related to chronic myeloid leukemia.

Application

Products | Products > Disease Areas > Blood Disease | Products > Disease Areas > Chronic Lymphocytic Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NAMPT | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-119159
• CAS No.: 361465-74-9
• Molecular Formula: C19H17N3O2
• Molecular Weight: 319.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source