DC-120

Overview

DC-120 is an ATP-competitive AKT inhibitor, with particular activity against AKT1 (an IC 50 of 0.153 μM). DC-120 functionally blocks AKT kinase activity and reduces the phosphorylation levels of FOXO3a and GSK-3β . DC-120 induces cancer cell apoptosis ( apoptosis ) and inhibits cancer cell proliferation. DC-120 activates the mTORC1 pathway via the Ca 2+ /calmodulin ( calmodulin )/ hVps34 signaling pathway. DC-120 abrogates AKT -mediated inhibition of CRAF , thereby activating the MEK/ERK MAPK pathway. DC-120 exerts anti-tumor activity in a nude mouse hepatocellular carcinoma xenograft model. DC-120 can be used for hepatocellular carcinoma-related research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Calmodulin | Products > Signaling Pathways > Raf | Products > Signaling Pathways > MEK | Products > Signaling Pathways > ERK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Akt | Products > Signaling Pathways > FOXO

Product Information

• Catalog No.: HY-119884
• CAS No.: 1261080-40-3
• Molecular Formula: C18H18Cl2N6OS
• Molecular Weight: 437.35
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source