UNC1666

Overview

UNC1666 is an ATP-competitive dual-target Mer / Flt3 tyrosine kinase inhibitor with IC 50 values of 0.55 nM and 0.69 nM, and K i values of 0.16 nM and 0.67 nM, respectively. UNC1666 reduces the phosphorylation levels of Mer and Flt3 , suppresses downstream pro-survival signaling pathways ( Erk1/2 , Akt and Stat ), induces cell apoptosis , and decreases colony formation of acute myeloid leukemia cells. UNC1666 is applicable to research related to acute myeloid leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > FLT3 | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-120089
• CAS No.: 1429882-12-1
• Molecular Formula: C26H35N5O4S
• Molecular Weight: 513.66
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source