NSC-134754 (NZ-28) is a dehydroemetine derivative and heat shock protein ( HSP ) induction inhibitor. NSC-134754 acts at the post-transcriptional level, targets Hsp72 and Hsp27 , and does not alter general protein synthesis, HSF-1 transcriptional activity, or Hsp mRNA levels. NSC-134754 can be used for the research of multiple myeloma, prostate carcinoma, colon carcinoma.
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