SMDC818909

Overview

SMDC818909 is an indole amide-derived uncompetitive inhibitor targeting p97 AAA+ ATPase , with an IC 50 of 3.5 μM and a K a of 9.1 μM. SMDC818909 binds to the D2 ATPase domain of p97 , preferentially associates with the ADP -bound conformation of p97 , allosterically blocks the ATP hydrolysis cycle of p97 , and inhibits its mediated intracellular protein homeostasis regulatory function. SMDC818909 is applied to the research and development of p97-targeted antitumor drugs, as well as studies on cancer-related proteotoxic stress mechanisms.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > p97

Product Information

• Catalog No.: HY-124253
• CAS No.: 1147823-21-9
• Molecular Formula: C14H13N5O
• Molecular Weight: 267.29
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source