CInQ-03

Overview

CInQ-03 is an allosteric inhibitor of MEK1/2 , with IC 50 values of 5 μM and 10 μM against MEK1 and MEK2 , respectively. CInQ-03 inhibits the kinase activity of MEK1/2 and reduces the phosphorylation levels of downstream ERK1/2 and RSK . CInQ-03 suppresses both anchorage-dependent and anchorage-independent growth of colon cancer cells, the activity of AP-1 reporter gene in colon cancer cells, as well as EGF -induced growth, transformation and AP-1 reporter gene activity in HaCaT keratinocytes. CInQ-03 can be used in studies related to colon cancer .

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MEK | Products > Signaling Pathways > PERK | Products > Signaling Pathways > Ribosomal S6 Kinase (RSK)

Product Information

• Catalog No.: HY-130453
• CAS No.: 500272-80-0
• Molecular Formula: C22H12ClN5O
• Molecular Weight: 397.82
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source