E7974

Overview

E7974 is a selective inhibitor of α-tubulin ( α-tubulin ) with an IC 50 of 3.9 μM. E7974 disrupts mitotic spindle formation, induces G 2 -M phase cell cycle arrest, initiates apoptosis , activates caspase-3 , and induces poly (ADP-ribose) polymerase cleavage. E7974 reduces the area of choroidal neovascularization in mouse models, and exerts anti-angiogenic effects when loaded in modified micelles. E7974 can be used in research related to cancer and choroidal neovascularization.

Application

Products | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-13614
• CAS No.: 610787-07-0
• Molecular Formula: C24H43N3O4
• Molecular Weight: 437.63
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source