BMS-37 hydrochloride

Overview

BMS-37 hydrochloride is a PD-1/PD-L1 immune checkpoint inhibitor with an IC 50 towards the PD-L1/PD-1 complex in the range of 18 to 200 nM. BMS-37 hydrochloride shows unspecific toxicity against modified Jurkat T cells with an EC 50 between 3 and 6 µM. BMS-37 hydrochloride can be used for the study of the PD-L1-induced exhaustion of T-cells or as PD-L1 ligand to synthesize PROTAC molecules.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PD-1/PD-L1

Product Information

• Catalog No.: HY-150879A
• CAS No.: 2108101-94-4
• Molecular Formula: C27H33ClN2O4
• Molecular Weight: 485.01
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source