HDAC-IN-54 is a HDAC inhibitor with an IC 50 of 25 nM against human HDAC1 , 66 nM against HDAC2 , 6.5 nM against HDAC3 , and 281 nM against HDAC6 . HDAC-IN-54 induces acetylation of α-tubulin and histone H3 . HDAC-IN-54 acts synergistically with cisplatin to induce cancer cell apoptosis . HDAC-IN-54 can be used in research related to head and neck cancer , ovarian cancer , and tongue squamous cell carcinoma.
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