Nagstatin is a naturally derived competitive inhibitor of N-acetyl-β-D-glucosaminidase ( NAG-ase ), with an IC 50 of 0.0012 μg/mL and a K i of 1.7×10 -8 M against porcine-derived enzyme. Nagstatin enhances cellular immune responses in normal mice and reactivates suppressed cellular immune responses in tumor-bearing mice. Nagstatin can be used in the research of various diseases such as diabetes and leukemia.
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