AGN-191659

Overview

AGN-191659 is an orally active RAR/RXR agonist with EC 50 values of 11 nM, 23 nM, and 37 nM for RXRα , RARβ , and RARγ , respectively. AGN-191659 activates RXRα , RARβ and RARγ to induce gene transcription. AGN-191659 induces tissue transglutaminase activity, inhibits ornithine decarboxylase activity induced by tumor promoters, and suppresses chondrogenesis. AGN-191659 reverses basic fibroblast growth factor-induced endothelial cell proliferation. AGN-191659 induces hypertriglyceridemia in rat models. AGN-191659 inhibits total heparin-releasable lipase activity. AGN-191659 can be used in research related to promyelocytic leukemia and hypertriglyceridemia.

Application

Products | Products > Disease Areas > Blood Disease | Products > Disease Areas > Hypertriglyceridemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > RAR/RXR

Product Information

• Catalog No.: HY-167262
• CAS No.: 156691-86-0
• Molecular Formula: C23H28O2S
• Molecular Weight: 368.54
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source