LDHA-IN-1 is a selective, competitive LDH-A inhibitor, with K i values of 8.9 μM (NADH assay) and 4.7 μM (Pyruvate assay) against hLDH-A. LDHA-IN-1 inhibits cancer cell proliferation under hypoxic conditions. LDHA-IN-1 can be used in the research of ovarian cancer , colorectal cancer , mesothelioma and pancreatic cancer .
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