P-gp-IN-30

Overview

P-gp-IN-30 (Compound 13) is a P-glycoprotein (P-gp) inhibitor by targeting YB-1 . P-gp-IN-30 significantly enhances sensitivity to Paclitaxel by reducing total YB-1 and nucleus YB-1 protein expression, inhibiting the expression and function of downstream P-gp, further suppressing the efflux rate of Paclitaxel . P-gp-IN-30 potently inhibits tumor growth in A549/Taxol xenografts mice model with combination of Paclitaxel ( HY-B0015 ). P-gp-IN-30 can be used for non-small cell lung cancer (NSCLC) research.

Application

Products | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > P-glycoprotein

Product Information

• Catalog No.: HY-175206
• CAS No.: 2761881-65-4
• Molecular Formula: C34H36N2O9
• Molecular Weight: 616.66
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source