TRK-IN-34

Overview

TRK-IN-34 is an orally active TRK and TRKC mutant kinase inhibitor, with IC 50 values of 0.75 nM and 0.96 nM against TRKA G595R and TRKA G667C , respectively. TRK-IN-34 inhibits the kinase activities of TRKA G595R and TRKA G667C at the functional level. TRK-IN-34 inhibits the proliferation of TRKA-transfected cells, exerts tumor growth-inhibitory effects and achieves partial tumor regression in xenograft models. TRK-IN-34 can be used to study TRK inhibitor-resistant cancers driven by the TRKA G667C mutation.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-181780
• CAS No.: 2489327-91-3
• Molecular Formula: C19H16F4N6O
• Molecular Weight: 420.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source