HOXA1-IN-1 is a HOXA1 inhibitor. HOXA1-IN-1 downregulates HOXA1 protein levels, suppresses its transcriptional activity, and alters the expression of its downstream target genes. HOXA1-IN-1 induces DNA damage and apoptosis in cancer cells. HOXA1-IN-1 exhibits antitumor efficacy in xenograft models of colorectal cancer and triple-negative breast cancer . HOXA1-IN-1 shows synergistic activity in combination with Cisplatin ( HY-17394 ). HOXA1-IN-1 can be used for the research of colorectal cancer and triple-negative breast cancer .
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