IKKβ-IN-6

Overview

IKKβ-IN-6 is an antitumor agent. IKKβ-IN-6 inhibits IKKβ ( IC 50 : 18.24 μM), thereby suppressing the phosphorylation of p65 and IκBα , blocking the nuclear translocation of p65, and subsequently regulating genes controlled by NF-κB . IKKβ-IN-6 also targets topoisomerase I ( Topo I ), induces DNA damage, ROS accumulation, loss of mitochondrial membrane potential, and S-phase arrest. IKKβ-IN-6 is applicable to related research on colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > IKK | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-181836
• CAS No.: 3117527-91-7
• Molecular Formula: C43H38N2O11
• Molecular Weight: 758.77
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source