CIRc-014

Overview

CIRc-014 is an orally active Cyclin A/B inhibitor with a Cyclin A IC 50 of 0.05 μM, Cyclin A K d of 2.7 nM, Cyclin B IC 50 of less than 0.02 μM and Cyclin B K d of 1.0 nM. CIRc-014 activates the spindle assembly checkpoint and promotes the formation of a complex between Cyclin B and CDK2 by blocking the RxL interaction of Cyclin A/B. CIRc-014 can induce replication stress, DNA damage, mitotic arrest and apoptosis in tumor cells. CIRc-014 showed tumor growth inhibition and regression in NCI-H69 and NCI-H446 small cell lung cancer xenograft models. CIRc-014 can be used for the research of small-cell lung cancer .

Application

Products | Products > Disease Areas > Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-181838
• CAS No.: 3064485-73-7
• Molecular Formula: C45H62ClF6N7O7
• Molecular Weight: 962.46
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source