MU262

Overview

MU262 is a MUS81 inhibitor with an IC 50 value of 0.87 μM. MU262 directly inhibits the catalytic activity of MUS81 without interfering with DNA binding, induces genomic instability in tumor cells, and specifically inhibits the HR/BIR repair pathway. The combination of MU262 with Cisplatin ( HY-17394 ) significantly enhances the chemotherapeutic killing effect. MU262 serves as a chemical biology tool for studying MUS81 function, and also acts as a lead compound for the development of anticancer therapies that exploit DNA repair defects in cancer cells.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Endonuclease

Product Information

• Catalog No.: HY-181840
• CAS No.: 1846587-13-0
• Molecular Formula: C20H15FN6O
• Molecular Weight: 374.37
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source