WS-691

Overview

WS-691 is an orally active, selective ABCB1 modulator. WS-691 selectively stabilizes ABCB1 via direct binding to ABCB1. WS-691 inhibits the efflux function of ABCB1 and activates ABCB1 ATPase activity. WS-691 elevates intracellular Paclitaxel ( HY-B0015 ) levels and reduces the required dose of Paclitaxel in cancer cells overexpressing ABCB1 . WS-691 increases the sensitivity of colon cancer cells to Paclitaxel .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > P-glycoprotein

Product Information

• Catalog No.: HY-182253
• CAS No.: 2035417-32-2
• Molecular Formula: C20H16FN7S
• Molecular Weight: 405.45
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source