YN11

Overview

YN11 is a STAT3 inhibitor ( K d =11.9 μM). YN11 directly binds to the SH2 domain of STAT3 , inhibits the phosphorylation of STAT3 , and reduces the expression of downstream target proteins. YN11 induces cell cycle arrest, promotes apoptosis , and inhibits cell invasion and migration in prostate cancer cells. YN11 suppresses tumor growth in a prostate cancer xenograft mouse model. YN11 does not cause significant body weight loss or obvious histopathological changes in major organs in xenograft mice. YN11 is applicable to relevant research on prostate cancer .

Application

Products | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-182288
• CAS No.: 3118507-43-7
• Molecular Formula: C25H22N2O8S
• Molecular Weight: 510.52
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source