NUAK1-IN-3

Overview

NUAK1-IN-3 is a potent and selective NUAK1 inhibitor with an IC 50 of 0.49 nM. NUAK1-IN-3 also inhibits NUAK2 and JAK3 with IC 50 values of 265 and 225 nM. NUAK1-IN-3 engages Glu139 of NUAK1 , forms a salt bridge between its bicyclic ring nitrogen and Asp142, and uses a fluorine atom to enhance hydrophobic binding interactions. NUAK1-IN-3 attenuates MYPT1 phosphorylation, suppresses the NUAK1-MYPT1 signaling axis, and inhibits proliferation, migration, and invasion of triple-negative breast cancer cells. NUAK1-IN-3 reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) marker alterations, downregulates Snail and N-cadherin , and upregulates E-cadherin in tumor tissues. NUAK1-IN-3 suppresses tumor growth in triple-negative breast cancer xenograft models. NUAK1-IN-3 can be used for the research of triple-negative breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Cadherin | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > JAK

Product Information

• Catalog No.: HY-182361
• CAS No.: 3097515-05-1
• Molecular Formula: C30H35ClFN7O6
• Molecular Weight: 644.09
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source