Vps34-IN-5 is an orally active VPS34 inhibitor, 98% target inhibition, and an IC 50 categorized as B. Vps34-IN-5 induces additive or synergistic anti-proliferative activity with EGFR inhibitors in cancer cells. Vps34-IN-5 is administered orally alone or with Erlotinib ( HY-50896 ) in mouse xenograft models. Vps34-IN-5 can be used for the research of non-small cell lung cancer .
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