A-849519

Overview

A-849519 is a reversible methionine aminopeptidase-2 ( MetAP-2 ) inhibitor with an IC 50 of 19 nM. A-849519 binds to the active site of the Mn 2+ form of human MetAP-2 , where the oxygen atom of one acidic functional group interacts with the manganese ion, and another heteroatom binds to the water molecule above the two manganese ions, thereby functionally inhibiting enzyme activity. A-849519 inhibits the methionine processing activity of MetAP-2 as well as the proliferation of fibrosarcoma cells. A-849519 can be used in studies related to fibrosarcoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MetAP

Product Information

• Catalog No.: HY-182419
• CAS No.: 904680-01-9
• Molecular Formula: C22H25FN2O4S
• Molecular Weight: 432.51
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source