G-963

Overview

G-963 is an allosteric inhibitor of mitogen-activated protein kinase kinase ( MEK ) with a MEK1 IC 50 of 0.012 μM. G-963 interacts with Ser212 of MEK and exhibits potent antiproliferative activity against HCT116 colon cancer cells ( EC 50 = 0.120 μM) and A375 melanoma cells ( EC 50 = 0.025 μM). G-963 can be used for the research of colon cancer , melanoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Melanoma | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > MEK

Product Information

• Catalog No.: HY-182538
• CAS No.: 1009330-74-8
• Molecular Formula: C16H13FIN3O4
• Molecular Weight: 457.19
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source