Hapalosin

Overview

Hapalosin is a multidrug resistance reversal agent and chemosensitizer with mild cytotoxicity against cancer cells. Hapalosin inhibits the ATP-dependent drug efflux pump function of P-glycoprotein and antagonizes multidrug resistance-associated proteins. Hapalosin reverses multidrug resistance mediated by P-glycoprotein and multidrug resistance-associated proteins, increases the intracellular accumulation of drugs transported by P-glycoprotein , and enhances the cytotoxicity of these drugs against cancer cells overexpressing P-glycoprotein . Hapalosin can be used in the research of multidrug-resistant cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > P-glycoprotein

Product Information

• Catalog No.: HY-182633
• CAS No.: 159542-04-8
• Molecular Formula: C28H43NO6
• Molecular Weight: 489.64
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source