RET-IN-32

Overview

RET-IN-32 is an orally active RET inhibitor with IC 50 values of 0.285, 4.602 and 103.5 nM against wild-type, V804M and G810S mutant forms, respectively. RET-IN-32 inhibits the autophosphorylation of Tyr1062. RET-IN-32 completely suppresses tumor growth induced by BAF3-KIF3B-RET-WT xenografts. RET-IN-32 can be used in the research of thyroid cancer and lung cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Thyroid Cancer | Products > Disease Areas > Thyroid Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Endocrinology | Products > Signaling Pathways > RET

Product Information

• Catalog No.: HY-182741
• CAS No.: 2620629-32-3
• Molecular Formula: C33H35N7O4
• Molecular Weight: 593.68
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source