BRD4/AKT-IN-1

Overview

BRD4/AKT-IN-1 is a BRD4 / AKT inhibitor with BRD4 IC 50 66.12 nM and AKT1 IC 50 143.81 nM. BRD4/AKT-IN-1 blocks BRD4 -mediated c-Myc transcriptional regulation, modulates AKT1 signaling, decouples AKT phosphorylation from pro-survival effectors. BRD4/AKT-IN-1 induces G0/G1 cell cycle arrest via downregulated phosphorylated RB , cyclin E1 , CDK2 . BRD4/AKT-IN-1 elevates LC3B levels to promote autophagy . BRD4/AKT-IN-1 promotes apoptosis in cancer cells. BRD4/AKT-IN-1 can be used for the research of metastatic castration-resistant prostate cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Castration-Resistant Prostate Cancer | Products > Disease Areas > Metastatic Prostate Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > Akt | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-183273
• CAS No.: 3087270-50-3
• Molecular Formula: C51H60ClN11O4
• Molecular Weight: 926.55
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source